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    Data / Companies / PTCT

    PTC Therapeutics, Inc.Nasdaq · S&P SmallCap 600

    PTCT-US · CIK 0001070081 · Pharmaceutical Preparations

    JSONEDGAR

    $60.59

    Last close · 23 Oct 2026

    59.27 – 89.55

    52-week range

    $5.0B

    Market value

    $1.0B

    Revenue, LTM · -42.8%

    -$38.4M

    Net income, LTM

    358

    Filings held

    DES OverviewFA Financial statementsGP ChartsRAT RatiosERN ResultsSEG SegmentsEVT 8-K eventsFIL FilingsINS Insider tradesF144 Planned salesHDS Large holdersOWN Fund holdersPAY Executive payVOTE Shareholder votesCNG House tradesSI Short interestDVD DividendsPEER PeersABT About

    PTCT US Equity

    OverviewDESFinancial statementsFAChartsGPRatiosRATResultsERNSegmentsSEG8-K eventsEVTFilingsFILInsider tradesINSPlanned salesF144Large holdersHDSFund holdersOWNExecutive payPAYShareholder votesVOTEHouse tradesCNGShort interestSIDividendsDVDPeersPEERAboutABT

    Revenue by quarter

    US$ · last 8
    Hover a column for its exact figure
    $0$500M$1B$1.5B
    Q3 '24Q4 '24Q1 '25Q2 '25Q3 '25Q4 '25Q1 '26Q2 '26
    QuarterRevenueNet incomeEPS
    Q2 FY2026$360.5M$83.5M0.92
    Q1 FY2026$272.6M-$2.8M-0.03
    Q4 FY2025$164.7M-$135.0M-1.67
    Q3 FY2025$211.0M$15.9M0.20

    Newest filings

    All 358
    FormFiled
    8-K21 Sep 2026
    8-K28 Aug 2026
    8-K13 Aug 2026
    10-Q30 Jul 2026
    8-K30 Jul 2026
    8-K18 Jun 2026
    8-K16 Jun 2026
    8-K9 Jun 2026

    Description

    Ticker
    PTCT-US
    Exchange
    Nasdaq
    Index
    S&P SmallCap 600
    Industry
    Pharmaceutical Preparations
    SIC division
    Manufacturing
    CIK
    0001070081
    LEI
    549300UJLWOIWFDGB318
    FIGI
    BBG000QT15P7
    Share class FIGI
    BBG001SNNC86
    Fiscal year ends
    Dec
    Filings held
    358 since 2004
    8-K events
    170
    Shares short
    9.2M, 30 Sep 2026

    Financial statements

    The income statement, balance sheet and cash flow by year and by quarter, line by line as the company reports them. Each column names the filing it comes from.

    34 lines · 15 years · US$ millionsJSON
    Fiscal periodFY2011FY2012FY2013FY2014FY2015FY2016FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025
    Period endingDec 2011Dec 2012Dec 2013Dec 2014Dec 2015Dec 2016Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024Dec 2025
    Source filing10-K10-K10-K10-K10-K10-K10-K10-K10-K10-K10-K10-K10-K10-K10-K
    Filed6 Mar 20142 Mar 201529 Feb 201616 Mar 20176 Mar 20181 Mar 20192 Mar 202025 Feb 202122 Feb 202221 Feb 202329 Feb 202427 Feb 202519 Feb 202619 Feb 202619 Feb 2026
    +Total revenues105M34Mr35Mr25M37M83M194M265M307M381M539M699M938M807M1,731M
    +Cost of product, collaboration and license sales, excluding amortization of acquired intangible assets–––––––13M12M19M32M45M66M57M47M
    +Amortization of acquired intangible assets––––0M0M15M23M28M37M55M117M223M61M25M
    +Research and development59M46Mr55Mr80M122M118M118M172M258M478M541M652M667M535M455M
    +Selling, general and administrative16M15Mr25Mr45M82M97M121M154M203M245M286M326M333M301M347M
    −Change in the fair value of contingent consideration–––––0M0M-19M-48M-23M0.5M26M128M4.5M0.8M
    +Intangible asset impairment–––––––––––33M218M160M–
    −Tangible asset impairment and losses on transactions, net–––––––––11M–––-0.7M9.6M
    −Total operating expenses75M61Mr80Mr125M204M215M259M380M548M813M913M1,146M1,377M1,109M864M
    Income from operations31M-27Mr-45Mr-99M-167M-132M-64M-116M-241M-432M-374M-447M-440M-303M867M
    % of total revenues29.0%-79.0%-130.8%-393.8%-454.6%-159.7%-33.1%-43.7%-78.6%-113.4%-69.5%-64.0%-46.9%-37.5%50.1%
    +Interest expense, net-2.4M-1.2Mr-6.1Mr1.2M-2.4M-8.3M-12M-13M-13M-56M-86M-91M-129M-167M-152M
    +Other income, net0.5M1.8Mr0Mr-0.2M-0.5M-1.2M-1.3M0.1M14M85M-58M-49M10M6.5M-18M
    +Gain on sale of priority review voucher–––––––––––––100M–
    +Loss on extinguishment of debt––-0.1Mr–––––––––-138M––
    Income before income tax benefit29M-26Mr-52Mr-98M-170M-142M-78M-128M-240M-403M-518M-588M-696M-363M697M
    % of total revenues27.1%-77.3%-148.6%-390.0%-462.3%-171.1%-40.0%-48.4%-78.2%-105.8%-96.2%-84.1%-74.2%-45.0%40.3%
    −Income tax benefit-2.3M––-4.7M0.5M0.6M1.3M-0M12M35M5.6M-29M-70M0.2M14M
    Net income attributable to common stockholders31M-26Mr-52Mr-94M-170M-142M-79M-128M-252M-438M-524M-559M-627M-363M683M
    % of total revenues29.3%-77.3%-148.6%-371.4%-463.6%-171.8%-40.6%-48.4%-82.0%-115.1%-97.3%-80.0%-66.8%-45.0%39.4%
    Basic and diluted––13M32M34M34M39M47M59M66M–––––
    Net loss per share-basic and diluted––-5.18-2.97-5.07-4.17-2.02-2.75-4.27-6.64–––––
    Basic0M0M13M32M––––59M66M71M72M75Mr77M80M
    Diluted0M0M13M32M––––59M66M71M72M75Mr77M88M
    Basic23.95219.76-5.18-2.97––––-4.27-6.64-7.43-7.79-8.37-4.738.58
    Diluted4.5542.50-5.18-2.97––––-4.27-6.64-7.43-7.79-8.37-4.737.78
    Revenue–––––83M194M265M307M––––––
    Cost of Goods and Services Sold––––––4.6M13M12M––––––

    Hover a figure for its source.r restated in a later filing– not reported in that period

    Lines in the order and wording of the 10-K filed 19 Feb 2026. 233 of 233 subtotals add up to the company's own totals, and the balance sheet balances in 67 of 67 periods. Newest filing read: 30 Jul 2026.

    Free for personal research, with credit (Data by Shikshan Nivesh) and a link. API access, bulk files and commercial use need a licence: the data licence.

    Charts

    Any figure or ratio in the record, by year, by quarter or on a trailing twelve months, as a value or as growth, against a peer if you like. Hover for the figures.

    Revenue · quarterly · US$

    Latest Jun 2026: $360.52M

    PTCT · PTC Therapeutics, Inc.20132026

    Revenue = rev

    $360.5M · Jun 2026
    101.5% · Jun 2026
    32.3% · Jun 2026
    96.0% · Dec 2019
    GrossOperatingNet
    $83.5M · Jun 2026
    −$39.7M · Jun 2026
    $0.92 · Jun 2026
    88.3M · Dec 2025
    $2.2B · Jun 2026
    CashDebt
    −44.5% · Dec 2025
    $711.2M · Dec 2025
    Operating cash flowCapital spending
    Revenue by segment
    Net product revenueRoyalty revenueTranslarnaManufacturing revenueCollaboration revenueEach fiscal year as its annual report gives it.

    Ratios

    Every ratio, worked out the same way for every company, by year or on a trailing twelve months. Hover a ratio for its formula.

    145 ratios · 12 in profitabilityJSON
    Fiscal year endingDec 2011Dec 2012Dec 2013Dec 2014Dec 2015Dec 2016Dec 2017Dec 2018Dec 2019Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024Dec 2025
    Return on common equity––−279.5%−43.1%−65.0%−82.2%−57.2%−50.5%−53.2%−81.4%−216.7%323.5%107.5%37.9%−104.7%
    Return on assets––−62.5%−38.7%−48.8%−44.8%−23.9%−17.0%−18.3%−22.9%−25.3%−30.7%−34.8%−20.2%29.7%
    Return on capital––−171.5%−43.5%−42.8%−39.0%−19.6%−28.7%−27.0%−40.1%−48.3%−129.5%255.5%35.5%−232.3%
    Return on invested capital––69.4%836.0%697.7%597.1%−105.5%−59.9%−76.5%750.5%90.6%161.7%49.5%14.2%−44.5%
    Gross margin––––100.0%100.0%97.6%95.2%96.0%––––––
    EBITDA margin31.7%−71.0%−123.9%−384.9%−446.8%−155.7%−24.0%−33.8%−68.1%−102.0%−57.6%−45.6%−21.6%−28.1%52.3%
    Operating margin29.0%−79.0%−130.8%−393.8%−454.6%−159.7%−33.1%−43.7%−78.6%−113.4%−69.5%−64.0%−46.9%−37.5%50.1%
    Incremental operating margin–80.3%−2477.7%571.5%−587.8%76.3%60.7%−73.1%−297.0%−258.3%36.3%−45.5%3.3%−104.5%126.6%
    Pretax margin27.1%−77.3%−148.6%−390.0%−462.3%−171.1%−40.0%−48.4%−78.2%−105.8%−96.2%−84.1%−74.2%−45.0%40.3%
    Profit margin29.3%−77.3%−148.6%−371.4%−463.6%−171.8%−40.6%−48.4%−82.0%−115.1%−97.3%−80.0%−66.8%−45.0%39.4%
    Net income to common margin29.3%−77.3%−148.6%−371.4%−463.6%−171.8%−40.6%−48.4%−82.0%−115.1%−97.3%−80.0%−66.8%−45.0%39.4%
    Effective tax rate−8.1%––4.8%−0.3%−0.4%−1.7%0.0%−4.9%−8.7%−1.1%4.8%10.0%−0.0%2.0%
    Hover a ratio for its formula as computed; avg() is the mean of the line now and a year earlier. The bar mark charts it. Worked out the same way for every company, from the standardized statements. Newest filing read: 30 Jul 2026.

    What the company said with its results

    The key points, guidance and management's own words from each of the last four results releases.

    Key points

    • Product revenue more than doubled

      Total net product revenue across the commercial portfolio was $238.8 million, against $118.3 million a year earlier. Total revenue was $360.5 million, against $178.9 million.

    • Net income against prior-year loss

      Net income was $83.5 million, or $0.92 per diluted share, against a net loss of $64.8 million, or $(0.83) per share, a year earlier.

    • Full-year revenue guidance raised

      Full-year total revenue and product revenue expectations were both raised for 2026. Figures are listed in the guidance section.

    • Sephience sales rose 21 percent

      Sephience net product revenue was $151.3 million, up 21% from the first quarter's $124.6 million. Patients on commercial therapy reached 1,647 at June 30, 2026, against 1,244 at March 31.

    • Sephience growth shifts beyond the US

      Sephience revenue was mostly from the US, with contributions from outside the US increasing. The company said the global launch continues.

    • Translarna and Emflaza revenue declined

      Translarna net product revenue was $42.2 million, against $59.5 million a year earlier. Emflaza was $24.6 million, against $36.4 million, due to continued generic erosion.

    • Evrysdi royalties grew

      Roche reported Evrysdi sales of approximately 968 CHF million year to date. PTC's royalty was $71.1 million for the quarter, against $57.6 million a year earlier.

    • Non-GAAP R&D expense fell

      Non-GAAP R&D expense was $88.6 million, excluding $10.5 million of stock-based compensation, against $104.0 million a year earlier.

    • GAAP R&D expense declined

      GAAP R&D expense was $99.2 million, against $113.0 million in the second quarter of 2025.

    • SG&A expense lower year over year

      GAAP SG&A expense was $80.6 million, against $85.3 million. Non-GAAP SG&A expense was $67.9 million, excluding $12.7 million of stock-based compensation, against $75.7 million.

    • Votoplam slowed disease at 10 mg

      PIVOT-HD 24-month results in Stage 2 participants showed dose-dependent slowing on the cUHDRS scale, reaching 52% at the 10 mg dose level.

    • Novartis-funded Phase 3 enrolling

      Novartis conducts and funds the INVEST-HD Phase 3 study, targeting about 770 people with early symptomatic disease. Its initiation triggered a $50 million milestone payment to PTC in the second quarter.

    • PTC303 named as development candidate

      PTC303 was named as the MSH3 splicing program development candidate, targeting Huntington's disease and myotonic dystrophy.

    • PTC612 Phase 1 started

      The oral NLRP3 inhibitor PTC612 entered a Phase 1 study in the second quarter of 2026.

    Guidance

    • Total revenue$1.18 to $1.28 billionfull year 2026 · raised from $1.08 to $1.18 billion
    • Total net product revenue$850 to $950 millionfull year 2026 · raised from $750 to $850 million
    • GAAP R&D and SG&A expense$775 to $815 millionfull year 2026 · kept from $775 to $815 million
    • Non-GAAP R&D and SG&A expense$680 to $720 millionfull year 2026 · kept from $680 to $720 million
    • Stock-based compensation expense (excluded from non-GAAP expense)$95 millionfull year 2026 · kept from $95 million

    In their words

    “Our teams delivered another strong quarter enabling us to again raise 2026 product revenue guidance” Matthew B. Klein, M.D., Chief Executive Officer
    “We also made a number of advances in our R&D pipeline, including identification of our next small molecule splicing development candidate, PTC303, targeting somatic expansion disorders including Huntington’s disease and myotonic dystrophy.” Matthew B. Klein, M.D., Chief Executive Officer
    “In addition, we initiated the Phase 1 study of PTC612, our differentiated NLRP3 small molecule.” Matthew B. Klein, M.D., Chief Executive Officer

    Coming up

    Vatiquinone study start. The PROVE-FA study is expected to start in Q3 2026.

    PTC844 Phase 2a start. The Phase 2a study of PTC844 is expected to start in Q3 2026.

    FDA engagement on PIVOT-HD. PTC plans to engage with the FDA in the second half of 2026 on the PIVOT-HD 24-month results, which are being finalized.

    PTC303 clinic entry. PTC303 is planned to enter the clinic in 2027.

    Revenue by segment

    As the company reports it in the segment note of each annual report: by business, by product and by region, latest year.

    By product, FY2024
    • Net product revenue$601.0M 74.5%
    • Royalty revenue$203.9M 25.3%
    • Manufacturing revenue$1.7M 0.2%
    • Collaboration revenue$304.0K 0.0%
    9 years held, FY2016 to FY2024
    By region, FY2024
    • United States$413.0M 51.2%
    • Non-US$393.7M 48.8%
    10 years held, FY2015 to FY2024

    Company events

    Every 8-K, sorted by the event it reports, with the moment the SEC accepted it in New York time.

    21 Sep 20268-KInvestor updateOther events7.01, 8.01, 9.01
    28 Aug 20268-KMaterial agreement1.01
    13 Aug 20268-KInvestor updateOther events7.01, 8.01, 9.01
    30 Jul 20268-KResultsLeadership changeInvestor update2.02, 5.02, 7.01, 9.01
    18 Jun 20268-KMaterial agreementNew debtShare saleOther events1.01, 2.03, 3.02, 8.01, 9.01
    16 Jun 20268-KOther events8.01, 9.01
    9 Jun 20268-KLeadership change5.02, 9.01
    5 Jun 20268-KShareholder vote5.07
    7 May 20268-KResultsInvestor update2.02, 7.01, 9.01
    28 Apr 20268-KInvestor update7.01, 9.01
    25 Mar 20268-KLeadership changeInvestor update5.02, 7.01, 9.01
    19 Feb 20268-KResultsInvestor update2.02, 7.01, 9.01
    12 Feb 20268-KInvestor update7.01, 9.01
    12 Jan 20268-KResultsInvestor update2.02, 7.01, 9.01
    29 Dec 20258-KMaterial agreement1.01
    4 Nov 20258-KResultsInvestor update2.02, 7.01, 9.01
    19 Aug 20258-KInvestor update7.01, 9.01
    7 Aug 20258-KMaterial agreement1.01
    7 Aug 20258-KResultsInvestor update2.02, 7.01, 9.01
    28 Jul 20258-KInvestor update7.01, 9.01
    17 Jun 20258-KShareholder vote5.07
    6 May 20258-KResultsInvestor update2.02, 7.01, 9.01
    5 May 20258-KInvestor update7.01, 9.01
    28 Mar 20258-KInvestor update7.01, 9.01
    27 Feb 20258-KResultsInvestor update2.02, 7.01, 9.01
    13 Jan 20258-KResultsInvestor update2.02, 7.01, 9.01
    3 Jan 20258-KMaterial agreementNew debt1.01, 2.03
    2 Dec 20248-KMaterial agreementInvestor update1.01, 7.01, 9.01
    27 Nov 20248-KMaterial agreementInvestor update1.01, 7.01, 9.01
    7 Nov 20248-KResultsInvestor update2.02, 7.01, 9.01
    18 Oct 20248-KInvestor update7.01, 9.01
    8 Aug 20248-KResultsInvestor update2.02, 7.01, 9.01
    28 Jun 20248-KInvestor update7.01, 9.01
    20 Jun 20248-KMaterial agreementShareholder voteInvestor update1.01, 5.07, 7.01, 9.01
    20 May 20248-KInvestor update7.01, 9.01
    25 Apr 20248-KResultsInvestor update2.02, 7.01, 9.01
    29 Feb 20248-KResultsInvestor update2.02, 7.01, 9.01
    25 Jan 20248-KInvestor update7.01, 9.01
    8 Jan 20248-KResultsInvestor update2.02, 7.01, 9.01
    26 Oct 20238-KResultsInvestor update2.02, 7.01, 9.01
    19 Oct 20238-KAgreement ended1.02, 9.01
    19 Oct 20238-KMaterial agreementInvestor updateOther events1.01, 7.01, 8.01, 9.01
    28 Sep 20238-KRestructuringInvestor update2.05, 7.01, 9.01
    22 Sep 20238-KOther events8.01, 9.01
    15 Sep 20238-KInvestor updateOther events7.01, 8.01, 9.01
    3 Aug 20238-KResultsInvestor update2.02, 7.01, 9.01
    19 Jul 20238-KInvestor updateOther events7.01, 8.01, 9.01
    17 Jul 20238-KLeadership change5.02, 9.01
    21 Jun 20238-KInvestor update7.01, 9.01
    6 Jun 20238-KShareholder vote5.07, 9.01
    1–50 of 150
    8-K events each year
    Hover a column for its exact count
    05101520
    '13'17'21'25'26

    Every filing

    The company's filings with the SEC, newest first: 358 held. Insider, fund and large-holder filings have their own tables below.

    21 Sep 20268-K21 Sep 2026
    28 Aug 20268-K25 Aug 2026
    13 Aug 20268-K12 Aug 2026
    30 Jul 202610-Q30 Jun 2026
    30 Jul 20268-K28 Jul 2026
    18 Jun 20268-K18 Jun 2026
    16 Jun 20268-K15 Jun 2026
    9 Jun 20268-K8 Jun 2026
    5 Jun 20268-K2 Jun 2026
    7 May 202610-Q31 Mar 2026
    7 May 20268-K7 May 2026
    28 Apr 20268-K28 Apr 2026
    20 Apr 2026ARS31 Jan 2026
    20 Apr 2026DEFA14A–
    20 Apr 2026DEF 14A2 Jun 2026
    25 Mar 20268-K24 Mar 2026
    19 Feb 202610-K31 Dec 2025
    19 Feb 20268-K19 Feb 2026
    12 Feb 20268-K12 Feb 2026
    12 Jan 20268-K12 Jan 2026
    29 Dec 20258-K29 Dec 2025
    4 Nov 202510-Q30 Sep 2025
    4 Nov 20258-K4 Nov 2025
    24 Sep 2025UPLOAD–
    18 Sep 2025CORRESP–
    21 Aug 2025UPLOAD–
    19 Aug 20258-K19 Aug 2025
    7 Aug 202510-Q30 Jun 2025
    7 Aug 20258-K5 Aug 2025
    7 Aug 20258-K7 Aug 2025
    28 Jul 20258-K28 Jul 2025
    17 Jun 20258-K17 Jun 2025
    6 May 202510-Q31 Mar 2025
    6 May 20258-K6 May 2025
    5 May 20258-K5 May 2025
    30 Apr 2025ARS31 Dec 2024
    30 Apr 2025DEFA14A–
    30 Apr 2025DEF 14A17 Jun 2025
    28 Mar 20258-K28 Mar 2025
    27 Feb 202510-K31 Dec 2024
    27 Feb 20258-K27 Feb 2025
    13 Jan 20258-K13 Jan 2025
    3 Jan 20258-K31 Dec 2024
    2 Dec 20248-K27 Nov 2024
    27 Nov 20248-K26 Nov 2024
    7 Nov 202410-Q30 Sep 2024
    7 Nov 20248-K7 Nov 2024
    18 Oct 20248-K18 Oct 2024
    8 Aug 202410-Q30 Jun 2024
    8 Aug 20248-K8 Aug 2024
    1–50 of 150

    Insider trades

    Form 4 trades by officers, directors and 10% owners, last 12 months, with the shares they held after.

    14 Oct 2026Schmertzler MichaelDirectorSale under a trading plan2,118$59.52$126.1K1,291,97616 Oct 2026
    14 Oct 2026Schmertzler MichaelDirectorSale under a trading plan382$60.14$23.0K1,291,59416 Oct 2026
    9 Oct 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan192$64.26$12.3K105,27213 Oct 2026
    7 Oct 2026Schmertzler MichaelDirectorSale under a trading plan2,447$63.38$155.1K1,294,1479 Oct 2026
    7 Oct 2026Schmertzler MichaelDirectorSale under a trading plan53$63.95$3.4K1,294,0949 Oct 2026
    6 Oct 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan435$64.16$27.9K105,2727 Oct 2026
    5 Oct 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan1,638$64.03$104.9K105,2727 Oct 2026
    30 Sep 2026Steele Glenn Jr Md PhdDirectorSale under a trading plan12,000$65.16$781.9K22,5002 Oct 2026
    17 Sep 2026Schmertzler MichaelDirectorSale under a trading plan9,624$67.83$652.8K1,296,97018 Sep 2026
    17 Sep 2026Schmertzler MichaelDirectorSale under a trading plan376$68.45$25.7K1,296,59418 Sep 2026
    16 Sep 2026Schmertzler MichaelDirectorSale under a trading plan2,994$66.58$199.3K1,313,60018 Sep 2026
    16 Sep 2026Schmertzler MichaelDirectorSale under a trading plan7,006$67.35$471.9K1,306,59418 Sep 2026
    10 Sep 2026Schmertzler MichaelDirectorSale under a trading plan10,000$67.34$673.4K1,316,59411 Sep 2026
    9 Sep 2026Schmertzler MichaelDirectorSale under a trading plan9,428$67.79$639.1K1,327,16611 Sep 2026
    9 Sep 2026Schmertzler MichaelDirectorSale under a trading plan572$68.67$39.3K1,326,59411 Sep 2026
    27 Aug 2026Schmertzler MichaelDirectorSale under a trading plan11,890$71.55$850.7K1,337,20428 Aug 2026
    27 Aug 2026Schmertzler MichaelDirectorSale under a trading plan610$72.22$44.1K1,336,59428 Aug 2026
    26 Aug 2026Schmertzler MichaelDirectorSale under a trading plan6,874$72.74$500.0K1,354,72028 Aug 2026
    26 Aug 2026Schmertzler MichaelDirectorSale under a trading plan5,626$73.18$411.7K1,349,09428 Aug 2026
    20 Aug 2026Schmertzler MichaelDirectorSale under a trading plan9,419$70.78$666.7K1,364,67521 Aug 2026
    20 Aug 2026Schmertzler MichaelDirectorSale under a trading plan2,390$71.88$171.8K1,362,28521 Aug 2026
    20 Aug 2026Schmertzler MichaelDirectorSale under a trading plan691$72.92$50.4K1,361,59421 Aug 2026
    19 Aug 2026Schmertzler MichaelDirectorSale under a trading plan5,335$72.86$388.7K1,381,25921 Aug 2026
    19 Aug 2026Schmertzler MichaelDirectorSale under a trading plan7,165$73.67$527.8K1,374,09421 Aug 2026
    17 Aug 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan1,844$72.39$133.5K106,24119 Aug 2026
    17 Aug 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan969$72.90$70.6K105,27219 Aug 2026
    4 Aug 2026Klein Matthew B.CHIEF EXECUTIVE OFFICERSale under a trading plan10,292$68.57$705.7K383,8686 Aug 2026
    14 Jul 2026Gravier PierreCHIEF FINANCIAL OFFICERSale under a trading plan3,494$80.35$280.7K83,98616 Jul 2026
    9 Jul 2026Smith Mary L.DirectorSale under a trading plan10,000$90.00$900.0K21,81313 Jul 2026
    9 Jul 2026Smith Mary L.DirectorSale under a trading plan5,834$90.00$525.1K21,81313 Jul 2026
    9 Jul 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSale under a trading plan2,464$90.25$222.4K60,29913 Jul 2026
    7 Jul 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSale under a trading plan3,956$87.17$344.8K80,9568 Jul 2026
    7 Jul 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSale under a trading plan11,369$89.03$1.0M69,5878 Jul 2026
    7 Jul 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSale under a trading plan9,288$89.44$830.7K60,2998 Jul 2026
    6 Jul 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan313$83.10$26.0K107,2258 Jul 2026
    6 Jul 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan833$84.41$70.3K106,3928 Jul 2026
    6 Jul 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan519$85.84$44.6K105,8738 Jul 2026
    6 Jul 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan601$86.38$51.9K105,2728 Jul 2026
    6 Jul 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan387$83.10$32.2K107,6988 Jul 2026
    6 Jul 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan1,036$84.41$87.4K106,6628 Jul 2026
    6 Jul 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan645$85.84$55.4K106,0178 Jul 2026
    6 Jul 2026Boulding Mark ElliottEXEC. VP AND CLOSale under a trading plan745$86.38$64.4K105,2728 Jul 2026
    6 Jul 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSale under a trading plan426$85.28$36.3K60,6848 Jul 2026
    6 Jul 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSale under a trading plan385$86.34$33.2K60,2998 Jul 2026
    6 Jul 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSale under a trading plan8,786$85.35$749.9K70,3898 Jul 2026
    6 Jul 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSale under a trading plan10,090$86.32$871.0K60,2998 Jul 2026
    6 Jul 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSale under a trading plan2,474$87.03$215.3K60,2998 Jul 2026
    26 Jun 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSale under a trading plan412$85.23$35.1K60,13730 Jun 2026
    26 Jun 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSale under a trading plan7,718$85.26$658.0K60,13730 Jun 2026
    25 Jun 2026Almstead Neil GregoryCHIEF TECHNICAL OPS OFFICERSale under a trading plan582$85.24$49.6K60,55626 Jun 2026
    1–50 of 150

    Planned insider sales

    Form 144 notices, filed when the sell order goes to the broker.

    9 Oct 2026Boulding Mark ElliottOfficer192$12.3K9 Oct 2026
    7 Oct 2026Section Six Partners, L.P.Affiliate of Director10,000$643.5K7 Oct 2026
    6 Oct 2026Boulding Mark ElliottOfficer435$27.9K6 Oct 2026
    5 Oct 2026Boulding Mark ElliottOfficer1,638$104.9K5 Oct 2026
    30 Sep 2026STEELE GLENN JR MD PHDDirector12,000$781.9K30 Sep 2026
    9 Sep 2026Section Six Partners, L.P.Affiliate of Director40,000$2.7M9 Sep 2026
    19 Aug 2026Michael SchmertzlerDirector50,000$3.6M19 Aug 2026
    17 Aug 2026Boulding Mark ElliottOfficer2,813$201.7K17 Aug 2026
    4 Aug 2026Klein Matthew B.Officer, Director10,292$705.8K4 Aug 2026
    14 Jul 2026Gravier PierreOfficer3,494$280.7K14 Jul 2026
    9 Jul 2026Almstead Neil GregoryOfficer2,464$222.4K9 Jul 2026
    9 Jul 2026Smith Mary L.Director15,834$1.4M9 Jul 2026
    7 Jul 2026Almstead Neil GregoryOfficer24,613$2.2M7 Jul 2026
    6 Jul 2026Boulding Mark ElliottOfficer5,079$427.3K6 Jul 2026
    6 Jul 2026Almstead Neil GregoryOfficer22,161$1.9M6 Jul 2026
    26 Jun 2026Almstead Neil GregoryOfficer8,130$693.1K26 Jun 2026
    25 Jun 2026Almstead Neil GregoryOfficer20,960$1.8M25 Jun 2026
    24 Jun 2026Almstead Neil GregoryOfficer5,323$452.6K24 Jun 2026
    22 Jun 2026Almstead Neil GregoryOfficer23,749$1.9M22 Jun 2026
    17 Jun 2026Boulding Mark ElliottOfficer10,522$827.6K17 Jun 2026
    17 Jun 2026Utter Christine MarieOfficer19,686$1.5M17 Jun 2026
    10 Jun 2026Pauwels EricOfficer21,277$1.6M10 Jun 2026
    15 May 2026Boulding Mark ElliottOfficer2,812$203.7K15 May 2026
    14 May 2026Klein Matthew B.Officer, Director2,572$186.4K14 May 2026
    14 May 2026Klein Matthew B.Officer, Director10,000$730.8K14 May 2026
    8 May 2026Boulding Mark ElliottOfficer3,540$279.6K8 May 2026
    21 Apr 2026Klein Matthew B.Officer, Director2,850$202.2K21 Apr 2026
    6 Apr 2026Boulding Mark ElliottOfficer2,265$157.3K6 Apr 2026
    2 Apr 2026Golden Lee ScottOfficer829$56.4K2 Apr 2026
    1 Apr 2026Almstead Neil GregoryOfficer52,003$3.6M1 Apr 2026
    12 Mar 2026Klein Matthew B.Officer, Director2,662$170.6K12 Mar 2026
    10 Mar 2026Okey StephanieDirector15,167$1.1M10 Mar 2026
    5 Mar 2026Almstead Zheng YangMember of immediate family of any of the foregoing3,989$252.8K5 Mar 2026
    5 Mar 2026Okey StephanieDirector6,333$401.4K5 Mar 2026
    5 Mar 2026Golden Lee ScottOfficer10,000$633.8K5 Mar 2026
    19 Feb 2026Boulding Mark ElliottOfficer3,019$207.0K19 Feb 2026
    18 Feb 2026Almstead Zheng YangMember of immediate family of any of the foregoing65$4.5K18 Feb 2026
    18 Feb 2026Golden Lee ScottOfficer2,484$172.3K18 Feb 2026
    18 Feb 2026Utter Christine MarieOfficer2,494$173.0K18 Feb 2026
    18 Feb 2026Gravier PierreOfficer2,992$207.5K18 Feb 2026
    18 Feb 2026Pauwels EricOfficer3,019$209.4K18 Feb 2026
    18 Feb 2026Almstead Neil GregoryOfficer3,056$212.0K18 Feb 2026
    18 Feb 2026Boulding Mark ElliottOfficer3,081$213.7K18 Feb 2026
    18 Feb 2026Klein Matthew B.Officer, Director7,371$511.2K18 Feb 2026
    17 Feb 2026Boulding Mark ElliottOfficer2,813$194.5K17 Feb 2026
    9 Jan 2026Boulding Mark ElliottOfficer2,314$180.3K9 Jan 2026
    9 Jan 2026Pauwels EricOfficer2,746$213.9K9 Jan 2026
    8 Jan 2026Almstead Zheng YangMember of immediate family of any of the foregoing59$4.5K8 Jan 2026
    8 Jan 2026Golden Lee ScottOfficer866$66.2K8 Jan 2026
    8 Jan 2026Almstead Neil GregoryOfficer881$67.4K8 Jan 2026
    1–50 of 80

    Large holders

    Schedule 13D and 13G filings by holders of more than 5% of the voting shares.

    15 May 2026JANUS HENDERSON GROUP PLC13G amended8.7%7.2M
    15 May 2026The Toronto-Dominion Bank13G amended3.7%3.0M
    30 Apr 2026Vanguard Capital Management13G5.17%4.3M
    29 Apr 2026Vanguard Portfolio Management13G5.88%4.9M
    27 Mar 2026The Vanguard Group13G amended0%0
    17 Feb 2026JANUS HENDERSON GROUP PLC13G6%4.9M
    13 Feb 2026The Toronto-Dominion Bank13G5.2%4.1M
    10 Feb 2026Wellington Management Group LLP13G amended4.82%3.9M
    9 Feb 2026STATE STREET CORPORATION13G5.2%4.2M
    4 Dec 2025BlackRock, Inc.13G amended14.8%11.9M
    14 Nov 2025Armistice Capital, LLC13G amended4.08%3.3M
    30 Oct 2025The Vanguard Group13G amended10.43%8.3M

    Trades by members of the House

    From each member's periodic transaction report: the amount is the band the report gives.

    No House trades in this company.

    Short interest

    Shares sold short and not yet bought back, on every FINRA settlement date.

    Shares short, each settlement
    30 Sep 20269.2M-5.86%6.14
    15 Sep 20269.7M-0.91%11.03
    31 Aug 20269.8M-3.84%12.13
    14 Aug 202610.2M-3.27%10.82
    31 Jul 202610.6M+7.45%7.52
    15 Jul 20269.8M-43.21%4.75
    30 Jun 202617.3M+46.94%5.36
    15 Jun 202611.8M+10.4%7.82
    29 May 202610.7M+4.23%11.08
    15 May 202610.2M+4.97%5.99
    1–10 of 211

    Funds that hold it

    Every fund's holding from its latest Form 13F, largest first, with what it added or trimmed in the quarter.

    Funds holding

    426

    quarter to 30 Jun 2026

    Added or new

    207

    since 31 Mar 2026

    Trimmed

    112

    in the quarter

    Largest holder

    BlackRock, Inc.

    $1.1B

    The 60 largest of 426 funds, by value
    BlackRock, Inc.$1.1B14.0M+1.0MAdded0.02%Filing ↗
    RTW Investments, LP$631.9M7.7M0Held5.39%Filing ↗
    Jupiter Topco LLC$590.2M7.2M–first0.24%Filing ↗
    Vanguard Portfolio Management LLC$402.0M4.9M+123.5KAdded0.02%Filing ↗
    State Street Corp.$375.1M4.6M+252.4KAdded0.01%Filing ↗
    Wellington Management Group LLP$336.7M4.1M+185.7KAdded0.06%Filing ↗
    Vanguard Capital Management LLC$305.0M3.7M+62.9KAdded0.01%Filing ↗
    Geode Capital Management, LLC$180.1M2.2M-2.6KTrimmed0.01%Filing ↗
    Toronto Dominion Bank$176.7M2.2M-860.1KTrimmed0.30%Filing ↗
    Westfield Capital Management Co. LP$159.6M2.0M+2.0MNew0.52%Filing ↗
    Hood River Capital Management LLC$141.8M1.7M+74.1KAdded1.03%Filing ↗
    William Blair Investment Management, LLC$140.5M1.7M+1.7MNew0.42%Filing ↗
    D. E. Shaw & Co., Inc.$126.3M1.5M-91.5KTrimmed0.08%Filing ↗
    Tang Capital Management LLC$122.4M1.5M0Held5.59%Filing ↗
    Bank of America Corp.$118.5M1.5M-434.6KTrimmed0.01%Filing ↗
    Driehaus Capital Management LLC$117.5M1.4M+424.3KAdded0.68%Filing ↗
    FMR LLC$114.1M1.4M-130.1KTrimmed0.01%Filing ↗
    Jefferies Financial Group Inc.$110.7M1.4M+2.6KAdded1.04%Filing ↗
    Fuller & Thaler Asset Management, Inc.$94.4M1.2M+1.2MNew0.26%Filing ↗
    Pictet Asset Management Holding SA$93.6M1.1M-35.9KTrimmed0.09%Filing ↗
    Price T Rowe Associates Inc.$90.9M1.1M+639.4KAdded0.01%Filing ↗
    Morgan Stanley$90.0M1.1M+429.5KAdded0.01%Filing ↗
    Armistice Capital, LLC$87.4M1.1M-1.0MTrimmed2.42%Filing ↗
    Blue Sparrow, LLC$85.7M1.1M+860.1KAdded0.83%Filing ↗
    Franklin Resources Inc.$83.8M1.0M-94.1KTrimmed0.02%Filing ↗
    Invesco Ltd.$76.8M941.6K+76.1KAdded0.01%Filing ↗
    Palo Alto Investors LP$75.0M918.8K-2.8KTrimmed10.36%Filing ↗
    Northern Trust Corp.$71.8M880.0K+73.8KAdded0.01%Filing ↗
    Charles Schwab Investment Management Inc.$64.4M790.1K+58.5KAdded0.01%Filing ↗
    Citadel Advisors LLC$61.0M747.8K+362.6KAdded0.04%Filing ↗
    Renaissance Technologies LLC$59.0M723.5K+190.2KAdded0.08%Filing ↗
    Boston Partners$58.6M718.6K+71.1KAdded0.05%Filing ↗
    Jupiter Asset Management Ltd$57.7M707.5K-4.0KTrimmed0.29%Filing ↗
    Marshall Wace, LLP$57.5M704.8K+244.1KAdded0.05%Filing ↗
    JPMorgan Chase & Co.$56.1M684.0K+338.0KAdded0.00%Filing ↗
    Arrowstreet Capital, Limited Partnership$53.4M654.4K+542.8KAdded0.02%Filing ↗
    Dimensional Fund Advisors LP$52.0M637.7K-253.0KTrimmed0.01%Filing ↗
    Goldman Sachs Group Inc.$50.4M618.2K-209.4KTrimmed0.01%Filing ↗
    SG Americas Securities, LLC$49.4M605.6K-274.1KTrimmed0.03%Filing ↗
    Loomis Sayles & Co. L P$48.2M590.4K+96.8KAdded0.06%Filing ↗
    Lord, Abbett & Co. LLC$48.1M590.1K-27.0KTrimmed0.14%Filing ↗
    Vanguard Fiduciary Trust Co.$48.0M587.9K+34.2KAdded0.01%Filing ↗
    Nuveen, LLC$47.6M583.8K-83.2KTrimmed0.01%Filing ↗
    Bank of New York Mellon Corp$45.1M553.5K+30.7KAdded0.01%Filing ↗
    Principal Financial Group Inc.$44.2M541.6K+26.6KAdded0.02%Filing ↗
    Voya Investment Management LLC$44.0M539.3K+196.7KAdded0.04%Filing ↗
    Ensign Peak Advisors, Inc$41.4M508.1K-74.3KTrimmed0.07%Filing ↗
    American Century Companies Inc.$40.9M501.0K+496.0KAdded0.02%Filing ↗
    Federated Hermes, Inc.$39.4M483.4K+257.5KAdded0.06%Filing ↗
    Manufacturers Life Insurance Company, the$36.1M442.0K+16.7KAdded0.03%Filing ↗
    1–50 of 60

    Executive pay and performance

    What the chief executive and the other named officers were paid, as reported and as actually paid, next to the shareholder return and net income, from each proxy's pay-versus-performance table.

    Pay versus performance
    6 fiscal years · from each proxy (DEF 14A)
    Fiscal yearCEO pay, as reportedCEO pay, actually paidOther officers, as reported (average)Other officers, actually paid (average)Shareholder return, $100Peer return, $100Net incomeRevenueProxy
    FY ending 31 Dec 2025$23.3M$41.2M$3.4M$7.1M$125$120$683.0M$1.73BDEF 14A 20 Apr 2026
    FY ending 31 Dec 2024$7.4M$14.7M$2.3M$4.5M$74$91$-363.3M$806.8MDEF 14A 20 Apr 2026
    FY ending 31 Dec 2023$8.9MMatthew Klein$5.7MStuart Peltz$4.8M$-3.5M$2.4M$0.8M$45$92$-626.6M$937.8MDEF 14A 20 Apr 2026
    FY ending 31 Dec 2022$7.2M$5.4M$3.4M$2.7M$63$89$-559.0M$698.8MDEF 14A 20 Apr 2026
    FY ending 31 Dec 2021$11.0M$-4.9M$4.3M$-1.0M$65$99$-523.9M$538.6MDEF 14A 20 Apr 2026
    FY ending 31 Dec 2020$10.6M$12.6M$4.0M$2.6M$127$126$-438.2M$380.8MDEF 14A 30 Apr 2025

    Each year from the newest proxy that reports it. Pay actually paid follows the SEC's definition and can be below zero when share awards fall in value. n the proxy's net income differs from the 10-K or was tagged without its scale: hover for which.

    Shareholder votes

    The vote count on every proposal at each meeting, from the company's 8-K.

    Meeting
    8-K, item 5.07, filed 5 Jun 2026
    ProposalForAgainst or withheldAbstainBroker non-votesFor, % of for and againstResult
    Proposal 1 (the filing doesn't name it)
    Jessica Chutter71,945,515737,780–3,858,31199.0%–
    Matthew B. Klein, M.D., M.S., F.A.C.S.71,550,8781,132,417–3,858,31198.4%–
    Stephanie S. Okey, M.S.68,902,7073,780,588–3,858,31194.8%–
    Jerome B. Zeldis, M.D., Ph.D.69,821,9432,861,352–3,858,31196.1%–

    Counts as the company reports them in its 8-K. A result shows when the filing states one. Meetings since 2023.

    Dividends and buybacks

    Dividend per share, the cash paid and the shares bought back, each fiscal year.

    This company has paid no dividend in the years held.

    Peers

    Companies in the same industry, largest first, on the same measures.

    CompanyMarket valueRevenue, 12 monthsRevenue growthOperating marginNet marginROEP/EEV/EBITDA
    PTC Therapeutics, Inc.this company$5.0B$1.0B-42.8%12.5%-3.8%––25.4×
    Eli Lilly & Co.$1.20T$79.7B49.6%–33.5%78.8%42.7×–
    Johnson & Johnson$635.2B$99.3B7.8%–16.2%19.7%40.0×–
    AbbVie Inc.$504.8B$64.4B10.4%26.2%9.8%–80.7×23.0×
    Merck & Co., Inc.$358.4B$66.6B4.6%–4.8%7.6%116.2×–
    Novartis AG$288.3B$54.5B8.4%––30.3%21.1×–
    AstraZeneca PLC$266.0B$58.7B8.6%23.4%17.4%21.0%26.2×–
    Abbott Laboratories$179.4B$46.6B8.1%15.8%11.6%10.6%33.6×19.2×
    Novo Nordisk A/S$174.3B$46.8B6.4%41.3%33.1%52.8%11.3×–
    Pfizer Inc.$171.1B$63.7B-0.2%–6.8%5.1%39.5×–
    Vertex Pharmaceuticals Inc.$132.7B$12.6B10.2%38.0%35.0%21.8%30.5×25.3×

    What the company does

    The description for this company is being written.

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    SN Data by Shikshan Nivesh · © 2026 Borkar Nexus Private LimitedData from public SEC, House and FINRA records. Not investment advice. info@shikshannivesh.com